Nerve Growth Factor (NGF) belongs to a family of proteins that play a part in maintenance, survival and regeneration of neurons during adult life. As we age, NGF declines, resulting in less efficient brain functioning. In mice, its absence leads to a condition resembling Alzheimer's disease.
Nerve Growth Factor has been shown to play a role in a number of diseases, such as coronary atherosclerosis, obesity, type 2 diabetes and metabolic syndrome. NGF could also be related to various psychiatric disorders, such as dementia, depression, schizophrenia, autism, Rett syndrome, anorexia and buliminia. NGF has been shown to accelerate wound healing, and there is evidence it could be useful for treating skin and corneal ulcers.
A breakthrough occurred when Hirokazu Kawagishi, PhD, discovered a class of compounds in Lion's Mane that stimulate production of NGF, causing neurons to regrow. These compounds called hericenones, are the first active substances found in natural products to induce NGF synthesis. Hericenones were isolated from the fruiting body of Lion's Mane and introduced into a culture containing astroglial cells obtained from rats. After 24 hours, an assay revealed that NGF was secreted into the culture medium.
Hericenones and other substances in Lion's Mane are believed to have great potential for repairing neurological damage, improving intelligence and reflexes, and, even more significant, preventing and treating Alzheimer's disease.
For more information and further discussion about Lion's Mane mushroom order The Power of the Lion's Mane Mushroom: Regenerate Your Brain with Lion's Mane by Ward W. Bond, PhD and Ken Babal, CN. Call 800-620-9975 for your FREE copy ($4.95 S&H).